TME iLab (Kashiwa-no-ha, Japan)

Open Innovation Hub for Tumor Microenvironment Research with Cutting-Edge Spatial Biology

This lab is to gain new insights into the tumor microenvironment for cancer drug discovery. It will leverage the Kashiwa-no-ha area, where leading Japanese cutting-edge medical facilities and academic institutions, including the National Cancer Center Japan, are located.

Features

Facilities

At TME iLab, we are focusing on generating innovation through discussions between internal and external researchers. We are promoting defining characteristics of the tumor microenvironment in clinical specimens, selecting biomarkers for effective therapies from clinical data, and identification of candidate target molecules.
Lab Space 334.18 m² (3^rd floor of MITSUI LINK-Lab KASHIWA-NO-HA 1)
Please visit the Mitsui Link-Lab Kashiwa-no-ha 1’s website to learn more about the common facilities of this building

Lab equipment

Cutting-edge spatial information analyzers and machine learning technologies including:
- Spatial molecular imager “CosMx SMI”,
- The system for spatial omics analysis “Xenium”
- The multifluorescent tissue profiler “Orion”,

Please click here to learn more about our equipment.

We are preparing the manual of the lab and equipment usage and to be announced as it becomes available.

Costs

Please contact us, if you have any questions about this facility.

Details

Lab Equipment

CosMx SMI (NanoString technologies, Inc.)

CosMx™ Spatial Molecular Imager (SMI) is high-plex in situ analysis platform to provide spatial multiomics with FFPE and fresh frozen　tissue samples at a single cellular and subcellular resolution. CosMx™ enables rapid quantification and visualization of up to 1,000 RNA and 64 validated protein analytes, and in January 2024 New 6K Discovery panel will enable analysis of entire Reactome at the single cell level.

Xenium (10x genomics, Inc.)

Xenium builds on years of innovation in single cell and spatial technologies of 10x genomics to deliver the most advanced end-to-end high-plex in situ platform on the market. The purpose-built design streamlines going from tissue section to data, with an automated analyzer, curated and/or custom panels, and intuitive visualization and analysis software. Xenium enables high-throughput subcellular mapping of 100s to 1,000s of RNA targets in addition to multiplexed protein on a tissue section.

Orion (Rarecyte, Inc.)

Orion is a benchtop, high resolution, whole slide multimodal imaging instrument enabling robust spatial biology studies and biomarker quantitation using a combination of quantitative immunofluorescence and bright field imaging.
Utilizing a swift sample-to-data workflow, all channels are acquired across the entire slide, in one scan, while rapid data processing enables whole slide, unbiased quantitation. By combining speed and resolution, Orion enables comprehensive phenotypic profiling and characterization of tissue architecture, tumor heterogeneity, and the immune response for whole sections in hours, not days.

Others

Real-Time PCR System, All-in-One Fluorescence Microscope, Multi-mode plate reader, NanoDrop, etc.

Please check here to learn more about MITSUI LINK-Lab KASHIWA-NO-HA 1 users’ shared lab equipment.

Close

Access

[MITSUI LINK-Lab KASHIWA-NO-HA 1]
Address: 6-6-2 Kashiwa-no-ha, Kashiwa City, Chiba
Access: 3 minutes by bus from “Kashiwanoha-campus” Station on the Tsukuba Express line,
3 minutes on foot from “Mitsui Garden Hotel Kashiwa-no-ha Park Side Mae (Zeikan Kenshujo)” bus stop