ESG data

Environment

The performance indicators marked with check_box have been independently assured by EY ShinNihon LLC. For details, please refer to the Independent Assurance Report.

check_box Independent Assurance Report (July 30^th 2026)

Reporting coverage, methods, etc.

Direct interaction between Astellas and the Environment (Results for FY 2025)

Direct Interaction

INPUT		OUTPUT
Energy^*1		GHGs^*1
Purchased electricity	190,088 MWh check_box Renewable derived 113,024 MWh check_box	Scope 1^*4	43,743 t-CO₂ check_box
		Scope 2	37,171 t-CO₂check_box
		Pollutants (atmosphere)^*5
Gaseous fuel	191,295 MWh check_box	NOx emissions^*5	14 tons check_box
Gaseous fuel	191,295 MWh check_box	VOC emissions^*5	21 tons check_box
Liquid fuel	44,338 MWh check_box	Water discharge, pollutants (water body)
Purchased heat	8,525 MWh check_box	Water discharge^*2	6,011 thousand m³ check_box
Direct use of renewable energy	16,019 MWh check_box	BOD load^*5	6 tons check_box
Direct use of renewable energy	(On-site electricity generation) 3,818 MWh check_box	COD^*5	18 tons
Resource		Waste material
Water withdrawal^*2	6,327 thousand m³ check_box	Volume of waste generated^*6	11,299 tons check_box
Raw materials and consumables (by weight)^*3	4,253 tons check_box	Landfill volume^*7	75 tons check_box

^*1All Astellas business facilities

^*2All production sites and R&D sites. (The volume of water discharge from overseas research sites and U.S. manufacturing sites was equivalent to that of withdrawal.)

^*3Items used at commercial production sites in Japan that can be ascertained on a weight or volume basis. Consumable supplies are those used in commercial production process.

^*4Non-energy-related GHG emissions are not included. The CO2 equivalent of fluorinated gases from all production sites and R&D sites in Japan was 518 t-CO2e. check_box

^*5All Astellas business facilities in Japan and overseas manufacturing and research sites

^*6All Japanese facilities, and all production and R&D sites outside of Japan

^*7All production sites ,R&D sites and distribution sites in Japan

Indirect GHGs (Scope 3)

（Unit：t-CO2e）

Upstream Scope 3 emissions		Downstream Scope 3 emissions
1. Purchased goods and services	957,768	9. Transportation and distribution (downstream)	15,928
2. Capital goods	81,671	10. Processing of sold products	out of disclosure scope
3. Fuel and energy related activities (not included in Scope 1 and Scope 2)	23,634	11. Use of sold products	out of disclosure scope
4. Transportation and distribution (upstream)	12,571	12. End-of-life treatment of sold products	210
5. Waste generated in operation	777	13. Downstream leased assets	1,660
6. Business travel (by airplane)	27,750	14. Franchises	out of disclosure scope
7. Employee commuting	1,888	15. Investments	out of disclosure scope
8. Upstream leased assets	out of disclosure scope

INPUT

Energy Consumption

Region	Type of energy	Unit	FY2022	FY2023	FY2024	FY2025
Global	Total Energy Consumption	MWh	581,432	558,039	494,739	450,265check_box
	renewable sourced	MWh	109,022	103,504	93,083	129,203check_box
	renewable energy ratio	MWh	19%	19%	19%	29%check_box
	Total Electricity^*1	MWh	227,486	228,688	207,703	198,804check_box
	renewable sourced	MWh	97,531	90,527	80,059	116,842check_box
	renewable energy ratio	MWh	42%	40%	39%	59%check_box
	Purchased electricity	MWh	225,526	226,691	205,273	190,088check_box
	renewable sourced	MWh	93,048	88,530	77,628	113,024check_box
	Gaseous fuel	MWh	267,124	252,061	210,279	191,295check_box
	Liquid fuel	MWh	53,894	56,069	55,942	44,338check_box
	Purchased thermal energy	MWh	8,722	8,244	7,790	8,525check_box
	Direct use of renewable energy	MWh	14,584	14,974	15,455	16,019check_box
	Self-generated electricity	MWh	1,960	1,997	2,431	3,818check_box
Japan	Purchased Electricity	MWh	407,447	387,641	349,301	317,096check_box
	renewable sourced	MWh	64,097	60,750	60,334	93,521check_box
	renewable energy ratio	MWh	16%	16%	17%	29%check_box
	Total Electricity^*1	MWh	167,468	167,217	161,660	154,120check_box
	renewable sourced	MWh	64,097	60,750	60,334	93,521check_box
	renewable energy ratio	MWh	38%	36%	37%	61%check_box
	Purchased electricity	MWh	167,420	167,043	160,803	148,477check_box
	renewable sourced	MWh	64,049	60,576	59,476	92,777check_box
	Gaseous fuel	MWh	226,994	209,395	177,842	162,523check_box
	Liquid fuel	MWh	12,903	10,969	9,795	5,351check_box
	Purchased thermal energy	MWh	82	60	4	0check_box
	Direct use of renewable energy	MWh	48	174	858	744check_box
	Self-generated electricity	MWh	48	174	858	744check_box
Overseas	Purchased Electricity	MWh	162,403	170,398	145,438	133,169check_box
	renewable sourced	MWh	43,536	42,754	32,750	35,682check_box
	renewable energy ratio	MWh	27%	25%	23%	27%check_box
	Total Electricity^*1	MWh	60,019	61,472	46,043	44,684check_box
	renewable sourced	MWh	30,911	29,777	19,725	23,321check_box
	renewable energy ratio	MWh	52%	48%	43%	52%check_box
	Purchased electricity	MWh	58,107	59,648	44,470	41,611check_box
	renewable sourced	MWh	28,999	27,954	18,153	20,248check_box
	Gaseous fuel	MWh	40,130	42,665	32,437	28,772check_box
	Liquid fuel	MWh	40,991	45,100	46,147	38,987check_box
	Purchased thermal energy	MWh	8,639	8,184	7,786	8,525check_box
	Direct use of renewable energy	MWh	14,536	14,800	14,597	15,275check_box
	Self-generated electricity	MWh	1,912	1,824	1,573	3,073check_box

^*1The total amount of purchased electricity, direct use of renewable energy (photovoltaic and wind power), and electricity generated by an internal co-generation facility. FY2025 data include electricity generated by a cogeneration facility, but FY2023/FY2024 data do not

Changes in Volume of Water Resources Withdrawn

Metric	Region	Water source	Unit	FY2016	FY2023	FY2024	FY2025
Water withdrawal	Global		thousand m³	8,774	6,497	6,883	6,327check_box
		Service water and industrial water	thousand m³	8,017	6,151	6,484	5,801check_box
		Ground water	thousand m³	758	346	399	527check_box
per market	Japan	Service water and industrial water	thousand m³	7,705	5,952	6,286	5,642
	Japan	Ground water	thousand m³	758	346	399	527
	US	Service water and industrial water	thousand m³	146	61	68	64
	US	Ground water	thousand m³	-	-	-	0
	Established Market	Service water and industrial water	thousand m³	145	124	111	75
	Established Market	Ground water	thousand m³	-	-	-	0
	China	Service water and industrial water	thousand m³	21	14	18	20
	China	Ground water	thousand m³	-	-	-	0
	International Market	Service water and industrial water	thousand m³	-	-	-	0
	International Market	Ground water	thousand m³	-	-	-	0
Sales Revenue			billion JPY	1,312	1,604	1,912	2,139
Water Resource Productivity			billion JPY/thousand m³	0.15	0.25	0.28	0.34check_box
% improvement（vs FY2016）					65%	86%	126%check_box

No water was withdrawn from a source other than service water, industrial water, or groundwater

Target: Production facilities and R&D sites in Japan and overseas

OUTPUT

GHG emissions volume (direct operataions)

Metric	Region	Unit	FY2015	FY2023	FY2024	FY2025
Scope 1^*1	Global	t-CO₂	84,756	57,124	52,212	43,743check_box
Scope 2 (market-based)	Global	t-CO₂	116,197	63,047	55,621	37,171check_box
Scope 1 + 2 (market-based)
Scope 1 + 2 (market-based) GHG emissions	Global	t-CO₂	200,953	120,171	107,833	80,915check_box
% reduction(vs FY2015)				-40%	-46%	-60%check_box
per market region	Japan	t-CO₂	154,447	92,325	82,224	53,435check_box
	Scope 1	t-CO₂	56,674	40,601	35,558	28,854check_box
	Scope 2	t-CO₂	56,674	92,325	46,666	24,580check_box
	Overseas	t-CO₂	46,506	27,846	25,609	27,480check_box
	Scope 1	t-CO₂	28,082	16,523	16,654	14,889check_box
	Scope 2	t-CO₂	18,424	11,323	8,955	12,591check_box
	US	t-CO₂	23,863	14,826	13,111	12,102
	EST	t-CO₂	14,666	6,314	6,212	6,017
	CN	t-CO₂	3,349	3,535	2,802	6,286
	INT	t-CO₂	4,628	3,172	3,485	3,076

^*1Non-energy-related GHG emissionsare not included. The CO2 equivalent of fluorinated gases from all production sites and R&D sites in Japan was 518 t-CO2e check_box

GHG emissions Volume by Activity

Metric	Unit	FY2015	FY2023	FY2024	FY2025
Emission from manufacturing and R&D sites	t-CO₂	154,706	100,860	90,743	66,548check_box
Emission from offices	t-CO₂	17,522	5,932	3,768	3,660check_box
Emissions from company vehicle use	t-CO₂	28,725	13,380	13,323	10,707check_box

GHG data（Scope 3 and Scope 1+2+3）

Metric	Unit	FY2015	FY2023	FY2024	FY2025
Scope 3 GHG emission	t-CO₂e	1,378,972	1,121,350	1,276,323	1,123,857check_box
% reduction (vs FY2015)		-	-19%	-7%	-19%
Scope 1 + 2 + 3 emissions (market-based)	t-CO₂	1,579,925	1,241,521	1,384,156	1,204,772check_box
% reduction (vs FY2015)		-	-21%	-12%	-24%
Scope 1 + 2 + 3 emissions (market-based) intensity (per sales revenue 1 billion JPY)	t-CO₂/billion JPY	1,151	774	724	563
% reduction (vs FY2015)		-	-33%	-37%	-51%

Scope 3 GHG emission per category

Category	Description	Unit	FY2015	FY2023	FY2024	FY2025
1	Purchased goods and services	t-CO₂e	1,099,263	857,945	1,082,536	957,768
2	Capital goods	t-CO₂e	144,053	178,421	90,582	81,671
3	Fuel and energy related activities (not included in Scope 1 and Scope 2)	t-CO₂e	28,400	29,755	27,410	23,634
4	Transportation and distribution (upstream)	t-CO₂e	17,837	14,946	19,987	12,571
5	Waste generated in operation	t-CO₂e	3,600	1,296	1,151	777
6	Business travel (by airplane)	t-CO₂e	53,528	21,496	34,056	27,750
7	Employee commuting	t-CO₂e	5,092	2,310	2,004	1,888
8	Upstream leased assets	t-CO₂e	out of disclosure scope	out of disclosure scope	out of disclosure scope	out of disclosure scope
9	Transportation and distribution (downstream)	t-CO₂e	26,392	14,668	15,048	15,928
10	Processing of sold products	t-CO₂e	out of disclosure scope	out of disclosure scope	out of disclosure scope	out of disclosure scope
11	Use of sold products	t-CO₂e	out of disclosure scope	out of disclosure scope	out of disclosure scope	out of disclosure scope
12	End-of-life treatment of sold products	t-CO₂e	807	242	246	210
13	Downstream leased assets	t-CO₂e	out of disclosure scope	271	3,301	1,660
14	Franchises	t-CO₂e	out of disclosure scope	out of disclosure scope	out of disclosure scope	out of disclosure scope
15	Investments	t-CO₂e	out of disclosure scope	out of disclosure scope	out of disclosure scope	out of disclosure scope

Changes in Water Discharges and BOD Load

Metric	Market region	Unit	FY2022	FY2023	FY2024	FY2025
Discharge Volume	Global	thousand m³	6,498	6,217	6,694	6,011check_box
	Japan	thousand m³	6,294	6,014	6,492	5,885check_box
	Overseas	thousand m³	204	203	201	126
	Japan	thousand m³	6,294	6,014	6,492	5,885check_box
	river	thousand m³	6,108	5,834	6,323	5,715check_box
	sewage	thousand m³	186	181	169	170check_box
BOD Load	Japan	metric ton	9	7	8	6check_box
	river	metric ton	6	5	7	5check_box
	sewage	metric ton	3	2	1	1check_box

Scope: Production sites and R&D sites

Waste Generation Volume

Metric	Region	Unit	FY2016	FY2023	FY2024	FY2025
kg generated	Global	metric ton	14,266	13,010	11,421	11,257check_box
	Japan	metric ton	11,726	9,354	8,736	8,515
	US	metric ton	54	921	720	501
	EST	metric ton	2,432	2,655	1,860	2,127
	CN	metric ton	54	81	104	114
	INT	metric ton	-	-	-	0
Sales Revenue		billion JPY	1,312	1,604	1,912	2,139
Waste Generation Intensity		metric ton/billion JPY	10.9	8.1	6.0	5.3check_box
% improvement （vs FY2016）				25%	45%	52%check_box

Scope: Production facilities and R&D sites in Japan and overseas

Emission of Air Pollutants

Air pollutant	Region	Unit	FY2022	FY2023	FY2024	FY2025
NOx emissions	Japan	metric ton	18	15	16	14check_box
VOC emissions	Japan	metric ton	23	22	22	21check_box

Scope: Production sites and R&D sites in Japan.
There are no use of heavy oil fueled equipments and no facilities that are subject to calculations for SOx (sulfur oxide) emissions.

Release and transfer of PRTR Chemical Substances in FY 2025

(Unit：tons)

Substance name	Volume handled	Volume released			Volume transferred
Substance name	Volume handled	Air	Water	Soil	Waste	Sewerage
Heptane	16.004 check_box	0.184 check_box	0.000 check_box	0.000 check_box	15.819 check_box	0.000 check_box
Chloroform	11.968 check_box	0.598 check_box	0.000 check_box	0.000 check_box	11.370 check_box	0.000 check_box
N-methyl-2-pyrrolidone	4.442 check_box	0.001 check_box	0.000 check_box	0.000 check_box	4.432 check_box	0.000 check_box
Hexane	3.106 check_box	0.140 check_box	0.000 check_box	0.000 check_box	2.966 check_box	0.000 check_box
Toluene	2.906 check_box	0.006 check_box	0.000 check_box	0.000 check_box	2.921 check_box	0.000 check_box

Tabulated based on the target substance list as indicated in the Order for the Enforcement of the PRTR Act, which came into effect on April 1, 2023.
Scope: Production sites and R&D sites in Japan.

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ESG data

Environment