Cell Therapy

Cell-based therapeutics have tremendous potential to satisfy unmet patient needs across a broad range of disease areas. They are also in their earliest stages of use within healthcare systems around the world, in only a handful of diseases. Those two facts put cell therapy at Astellas’ sweet spot, turning innovative science into VALUE for patients. There is still so much to explore in terms of both where the science can go and how it can help patients, particularly those for whom no other treatment exists.

Over the last few years, we have acquired and developed the means to create a broad portfolio of different cell types. We collaborate with leading minds in a variety of therapeutic areas to fully explore the potential of cell therapy for treating diseases with high unmet medical need and unlock the VALUE that it can provide to patients. We also work hard to apply the latest technologies to the development of these therapies which allows us to stay at the forefront of breakthroughs in this fast-paced and emerging new field. Our goal is to develop “off-the-shelf” cell-based therapies that can be used in any patient and so we are working at the intersection of cell science and genetic science to develop the cell-based therapies of the future. The field of cell-based therapies truly excites us because we believe through our scientific expertise, we can make a difference for patients.

Our leading programs in Cell Therapy

Our most clinically-advanced program is looking at the use of retinal pigmented epithelium cells for improving vision in patients with dry age-related macular degeneration. We also have several other ocular cell types in our portfolio, such as Photoreceptor Cells, Corneal Endothelial Cells and Retinal Ganglion Cells. Our lead asset in the non-ocular space is our human hemangioblast-derived mesenchymal stem cell program, which has the potential to be of use in a wide range of conditions and diseases that involve immune response. This is closely followed by our Vascular Progenitor Cell asset with potential to add value in areas such as chronic limb ischemia and pulmonary hypertension.

Astellas has evolved cell therapy, which is our important modality platform, and the organic application of cell therapy platforms is progressing in multiple primary focus strategies.

Cell Therapy image


Collaborations based on assets, capabilities and talent that we are seeking to build 

We have built expertise in many of the capabilities required to successfully realize the promise of cell-based therapies. Within Research, pluripotent stem cell sourcing, Universal Donor Cell technology, gene editing and differentiation are key to our activities. We then apply expertise in standardization, quality assurance and knowledge of GMP manufacturing, freeze/thaw technology and formulation to move from the lab to manufacturing cells for clinical use. We continue to evolve our capabilities to create and deliver VALUE. We collaborate with partners who have expertise and capabilities complementary to our own in order to accelerate the development of our cell-based therapies.

[Assets and capabilities

  • Immune evasion approaches including universal donor cell and immune cloaking technologies
  • Genetic engineering approaches for controllable gene expression to enhance maturation and/or therapeutic effects of our cells
  • Real world evidence and patient omics (genomics, transcriptomics, etc.) data sets in various disease states to help understand areas of highest patient unmet medical need and to identify those who are most likely to respond to our cellular therapies
  • Automation, cryopreservation, and/or labelling/tracking technologies that can be applied to cellular therapies


  • Regulatory and CMC know-how in the development of engineered cellular therapies
  • Histopathology and preclinical/clinical expertise in various disease areas including retinal degeneration, vascular disease, autoimmune diseases, etc.


Message from Primary Focus Lead

Message from AIRM President

Yoshitsugu Shitaka, Ph.D. 
Astellas Institute for Regenerative Medicine

The science of cell therapy and its application to healthcare still has much to discover and so cell therapy represents far-reaching opportunities for patients and innovators alike. At Astellas, we have made significant investments in building the capabilities, resources, expertise, technology and portfolio needed to realize this potential. We believe that to be successful, it is essential to look to the future and consider how we can contribute to creating and delivering on the promise of cell therapy for patients.  In the end, the path forward must include partners and collaborations. If you feel the same, we’d like to hear from you.


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