TOKYO – May 16, 2018 – Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D., “Astellas”) announced today that a wide selection of abstracts highlighting the Company’s diverse oncology portfolio across a broad range of cancers have been accepted for oral and poster presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, June 1-5 in Chicago. Highlights of the data and studies being presented include findings for: men with non-metastatic Castration-Resistant Prostate Cancer (CRPC) taking enzalutamide* and androgen deprivation therapy; patients with locally advanced or metastatic urothelial cancer taking enfortumab vedotin**, an investigational antibody-drug conjugate (ADC); and patients taking gilteritinib in Phase 3 trial in FLT3 mutation-positive (FLT3mut+) acute myeloid leukemia (AML). 

“The Astellas abstracts accepted for presentation at this year’s ASCO meeting demonstrate the depth and breadth of our growing leadership in oncology across a broad range of cancers,” said Steven Benner, M.D., senior vice president and global therapeutic area head, Oncology Development, Astellas. “These data demonstrate the strength and progress of our oncology pipeline driven by investment in R&D and collaborative partnerships.”

The following will be presented during an oral presentation: 

Title: (Abstract 4504) Updated Results from the enfortumab vedotin Phase 1 (EV-101) Study in Patients with Metastatic Urothelial Cancer (mUC) 

Presenter: Jonathan E. Rosenberg, MD
•    Session Date/Time:  June 3, 9:12 AM – 9:24 AM CDT
•    Oral Abstract Session: Genitourinary (Nonprostate) Cancer 
•    Location: Arie Crown Theater

Additionally, the following data will be shared during poster presentations:

Title: (Abstract TPS4590) EV-201 Study: A Single-Arm, Open-Label, Multicenter Study of enfortumab vedotin for Treatment of Patients with Locally Advanced or Metastatic Urothelial Cancer who previously Received Immune Checkpoint Inhibitor Therapy

Presenter: Jonathan E. Rosenberg, MD 
•    Session Date/Time: June 2, 8:00 AM – 11:30 AM CDT
•    Poster Session: Genitourinary (Nonprostate) Cancer
•    Location: Hall A


Title: (Abstract 5010) Health-Related Quality of Life (HRQoL) Deterioration and Pain Progression in Men with Non-Metastatic Castration-Resistant Prostate Cancer (M0-CRPC): Results from the PROSPER study

Presenter: Gerhardt Attard, MD, PhD
•    Session Date/Time: June 2, 1:15 PM – 4:45 PM CDT
•    Poster Session: Genitourinary (Prostate) Cancer
•    Location: Hall A
•    Poster Discussion Session on June 2, 2018, 4:45 PM - 6:00 PM CDT, at S406

Title: (Abstract 5043) Association Between Health-Related Quality of Life (HRQoL) and clinical outcomes in non-metastatic castration-resistant prostate cancer (M0 CRPC): Results from the PROSPER study

Presenter: Gerhardt Attard, MD, PhD
•    Session Date/Time: June 2,1:15 PM – 4:45 PM CDT
•    Poster Session: Genitourinary (Prostate) Cancer
•    Location: Hall A

Title: (Abstract TPS7075) A Phase 3, Trial of Gilteritinib, as Maintenance Therapy after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with FLT3-ITD + AML

Presenter: Mark J. Levis, MD, PhD
•    Session Date/Time: June 4, 8:00 AM – 11:30 AM CDT
•    Poster Session: Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
•    Location: Hall A

*Enzalutamide is developed through a collaboration between Pfizer and Astellas and commercialized under the brand name XTANDI®.
**Enfortumab vedotin is developed through a collaboration between Seattle Genetics and Astellas