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| 1923 | Yamanouchi Yakuhin Shokai started by Kenji Yamanouchi in Osaka. (renamed Yamanouchi Pharmaceutical Co., Ltd. in 1940 and transferred to Tokyo in 1942) |
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| 1963 | Established Taiwan Yamanouchi Pharmaceutical Co., Ltd. (first business base in overseas) |
| 1979 | New York Office opened (first business base in the U.S.) |
| 1980 | London Office opened (first business base in Europe) |
| 1986 | Established Yamanouchi Ireland Co., Ltd. (first overseas production base for bulk drug substances) |
| 1991 | Established an independent marketing organization in Europe by acquiring the pharmaceutical division of Royal Gist Brocades (renamed Yamanouchi Europe B.V. in 1994) |
| 1994 | Established Shenyang Yamanouchi Pharmaceutical Co., Ltd. in China (renamed Yamanouchi Pharmaceutical (China) Co., Ltd. in 2002) |
| 2001 | Established Yamanouchi Pharma America, Inc. in the U.S. (in preparation for full-scale marketing in the U.S.) |
| 1894 | Fujisawa Shoten started by Tomokichi Fujisawa in Osaka (renamed Fujisawa Pharmaceutical Co., Ltd. in 1943) |
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| 1962 | Established Fujisawa Pharmaceutical Co., (Taiwan) Ltd. (first overseas business base after World War II; renamed Fujisawa Taiwan Co., Ltd. in 1994) |
| 1977 | Established Fujisawa Pharmaceutical Corporation (first business base in the U.S.) |
| 1979 | Established Fujisawa London Office (first business base in Europe) |
| 1983 | Acquired minority stake in Klinge Pharma GmbH of Germany (majority ownership acquired in 1988; became a fully owned company and renamed Fujisawa Deutschland GmbH in 2002) |
| 1990 | Established Fujisawa USA, Inc. in the U.S., following the total acquisition of Lyphomed, Inc., a company in which Fujisawa had invested since 1985 |
| 1991 | Established Fujisawa GmbH in Germany |
| 1998 | Reorganized U.S. business structure, creating Fujisawa Healthcare, Inc. |
| 2001 | Restructured the European operations and positioned Fujisawa GmbH as the European headquarters |
| 2004 | Reorganized operations in China, Hong Kong and Taiwan |
April 1, 2005
Astellas Pharma Inc. was established